NITRIC OXIDE AS A MODIFIER OF RADIATION EFFECTS ON SHIGELLA FLEXNERI
Journal Article
·
· Intern. J. Radiation Biol.
The mode of action of NO as a modifier of radiation sensitivity in aqueous suspensions of Shigella flexneri is different from that of O/sub 2/. NO present during irradiation has a sensitizing effect which is similar, but not chemically equivalent, to that due to O/sub 2/. Exposure to NO followed by removal of the gas prior to irradiation (i.e., pre-treatment) causes a latent irreversible effect on the bacteria, which becomes manifest after irradiation as enhanced radiation sensitivity dependent on concentration of NO and on the time of contact. NO has also a relative protective effect. A tentative hypothesis based on the fixation of NO by unknown cell constituents is suggested. (auth)
- Research Organization:
- Christie Hospital, Manchester, Eng.
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-16-012894
- OSTI ID:
- 4800437
- Journal Information:
- Intern. J. Radiation Biol., Journal Name: Intern. J. Radiation Biol. Vol. Vol: 4
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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