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U.S. Department of Energy
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'NITRIC OXIDE-AND OXYGEN EFFECT' IN X-IRRADIATED SHIGELLA FLEXNERI

Journal Article · · Nature
DOI:https://doi.org/10.1038/189851a0· OSTI ID:4053836

BS>Results of studies on the effects of nitric oxide on the radiosensitivity of Shigella flexneri led to the conclusion that the effect produced is due largely to some latent, irreversible injury to unknown constituents of the cells with which nitric oxide may combine. This injury is revealed on subsequent irradiation. The nitric oxide effect is thus different from the oxygen effect, which is only seen when irradiation occurs in the presence of the gas. The effect of time of contact with, and of ths concentration of nitric oxide during pre-treatment does not support the equivalence of nitric oxide and oxygen in their role in enhancing injury by radiation. (C.H.)

Research Organization:
Christie Hospital and Holt Radium Inst., Manchester, Eng.
Sponsoring Organization:
USDOE
NSA Number:
NSA-15-014155
OSTI ID:
4053836
Journal Information:
Nature, Journal Name: Nature Vol. Vol: 189
Country of Publication:
Country unknown/Code not available
Language:
English