On the Mechanism of the Radioprotective Action of Cyanide
Journal Article
·
· International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine
The mechanism of the radioprotective action of cyanide was investigated with rat-thymocyte suspensions, cultured human-kidney cells, and with mice. Cyanide does not protect cells in vitro. In the thymocytc system, cyanide has instead a slight radiosensitizing action. The presence of cyanide after the irradiation causes an inhibition of the development of eosin permeability. In mice, cyanide produces a hypoxia of the spleen and bone-marrow. This hypoxia explains the protection against a lethal dose of x rays.
- Research Organization:
- National Defence Research Organization T.N.O., Rijswijk, Netherlands
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-16-012941
- OSTI ID:
- 4797204
- Journal Information:
- International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine, Journal Name: International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine Journal Issue: 3 Vol. 4; ISSN 0020-7616
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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