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Radioprotective action on bone marrow CFU during immobilization of mice. [X Radiation]

Journal Article · · Radiat. Res.; (United States)
DOI:https://doi.org/10.2307/3574400· OSTI ID:7187432
;

Anesthesia and restraint without anesthesia during whole-body x-irradiation decrease the mortality from both the bone marrow and the intestinal syndromes (30- and 5-day mortality). The two types of immobilization decrease the radiosensitivity of the hemopoietic stem cells, as shown by an increased survival of hemopoietic stem cells in the marrow of immobilized mice. The hypoxic cell radiosensitizer Ro-07-0582 reversed the radioprotective effect during restraint without anesthesia, but not during pentobarbital anesthesia. This indicates that hypoxia of the femur bone marrow cannot explain the decreased radiosensitivity of the stem cells during pentobarbital anesthesia. Pentobarbital was also shown to inhibit the recruitment of resting femur bone marrow stem cells (G/sub 0/-phase cells) into cycle following a sublethal dose of x rays. The relevance of these observations is discussed.

Research Organization:
Radiobiological Inst., Leiden
OSTI ID:
7187432
Journal Information:
Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 66:2; ISSN RAREA
Country of Publication:
United States
Language:
English

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Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANESTHESIA
ANIMAL CELLS
ANIMALS
ANOXIA
AZINES
BARBITURATES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BONE MARROW
CFU
DIGESTIVE SYSTEM
DRUGS
ELECTROMAGNETIC RADIATION
GASTROINTESTINAL TRACT
HEMATOPOIETIC SYSTEM
HETEROCYCLIC COMPOUNDS
HYPNOTICS AND SEDATIVES
INTESTINES
IONIZING RADIATIONS
MAMMALS
MICE
MORTALITY
NEMBUTAL
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
PYRIMIDINES
RADIATION EFFECTS
RADIATION PROTECTION
RADIATIONS
RADIOSENSITIVITY
RADIOSENSITIVITY EFFECTS
RADIOSENSITIZERS
RESPONSE MODIFYING FACTORS
RODENTS
SOMATIC CELLS
STEM CELLS
TISSUES
VERTEBRATES
X RADIATION