THE RADIOPROTECTION OF THYMOCYTES IN RATS BY MEANS OF INDOLE DERIVATIVES (in Russian)
The compounds 5-methoxytryptamine, which show good radioprotective properties in mice, 6-methoxytryptamine, which is a poor radioprotective agent, and delta -3-indolylbutylamine, which has no effect on the outcome of radiation sickness in mice, were used to study the radioprotective properties of amines of the indole series under in vitro conditions. Dead thymocytes are stained by eosin and are used to follow the radioprotective properties of the indole compounds. A suspension of thymocytes in a Ringer solution was isolated from the thymus of young, decapitated rats, and was given an x-ray dose of 1300 r. The percent survival of the cells was calculated with respect to the unirradiated control. The compounds 5- and 6methoxytryptamine gave a cell survival of about 87% and 75% when added to the thymocyte suspension in concentrations of 1: 4000 and 1: 40,000, respectively. Without addition of the radioprotective agent, the cell survivals were 63 and 67%, respectively. The compound delta -3- indolylbutylamine was toxic at a concentration of 1:4000, and gave a cell survival of 17.5% with addition of reagent, and 67.9% without addition of the reagent. However, at a concentration of 1:40,000 this compound showed radioprotective properties. The cell survival was 80.3% with addition of the reagent and 66.7% without addition of the reagent. The protective effect for all three is the same in vitroi and cannot be correlated with the protective effect of these compounds in vivo. (TTT)
- Research Organization:
- Originating Research Org. not identified
- NSA Number:
- NSA-17-030426
- OSTI ID:
- 4677451
- Journal Information:
- Radiobiologiya (U.S.S.R.) For English translation see Radiobiology (Engl. Transl.), Journal Name: Radiobiologiya (U.S.S.R.) For English translation see Radiobiology (Engl. Transl.) Vol. Vol: 3; ISSN RADOA
- Country of Publication:
- Country unknown/Code not available
- Language:
- Russian
Similar Records
CHEMICAL PROTECTION OF RAT THYMOCYTES IRRADIATED IN VITRO
EFFECT OF CALCIUM SALTS ON THE RADIOSENSITIVITY OF RAT THYMOCYTES
Related Subjects
AMINES
ANIMAL CELLS
ATOMIC MODELS
BIOLOGY AND MEDICINE
BUTYL RADICALS
COLLISIONS
CROSS SECTIONS
DYES
EFFICIENCY
ELECTRIC CHARGES
EMISSION
ENERGY
ENERGY LEVELS
ENERGY RANGE
EOSIN
EXCITATION
HELIUM
INDOLES
INTERACTIONS
IONIZATION
IONS
IRRADIATION
MATHEMATICS
MEASURED VALUES
MICE
ORGANIC NITROGEN COMPOUNDS
PROTONS
QUANTITY RATIO
RADIATION DOSES
RADIATION PROTECTION
RATS
SOLUTIONS
SPECTRA
SURVIVAL TIME
SUSPENSIONS
THYMUS
TOXICITY
TRANSIENTS
TRYPTAMINES
VARIATIONS
X RADIATION