THE RADIOPROTECTION OF THE HEMATOPOIETIC ORGANS OF MICE BY MEANS OF A NUMBER OF CHEMICAL COMPOUNDS

Journal Article · Mon Dec 31 23:00:00 EST 1962 · Radiobiologiya (U.S.S.R.) For English translation see Radiobiology (Engl. Transl.)

OSTI ID:4677415

Lebkova, N P; Shevchenko, A N

White mice were given an x-ray dose of 700 r ten minutes after injection with a radioprotective compound. The mice were killed 4 hours after the irradiation, and the number of degenerate cells per 3 to 5 thousand healthy cells was determined. The protective effect on the hematopoietic organs can be correlated with the survival data available for these compounds. Thus, 5- methoxytryptamine was more effective than mercamine and tryptamine in protecting the hematopoietic organs of the mice, and gamma -3-indolylpropylamine and delta -indolylbutylamine showed very little protective effect. A combination of mercamine and 5-methoxytryptamine was more effective than a combination of mercamine and tryptamine. The introduction of alpha -methyltryptamine, which is an inhibitor of monoamineoxidase, an hour before irradiation has an adverse effect on the protective action of 5-methoxytryptamine. All the radioprotective compounds noticeably decrease the destruction of cells in the hematopoietic organs, and there is a definite correlation between the magnitude of the decrease in cell destruction and the effect of the radioprotective compound on the survival of irradiated animals. Experiments with mercamine at an irradiation dose of 200 r showed that the optimal protective dosage of 150 mg/kg of the compound was more effective in decreasing the number of degenerate cells and chromosomal aberrations than a lower dosage of 75 mg/kg of mercamine. (TTT)

• Research Organization: Originating Research Org. not identified
• NSA Number: NSA-17-030427
• OSTI ID: 4677415
• Journal Information: Radiobiologiya (U.S.S.R.) For English translation see Radiobiology (Engl. Transl.), Journal Name: Radiobiologiya (U.S.S.R.) For English translation see Radiobiology (Engl. Transl.) Vol. Vol: 3; ISSN RADOA
• Country of Publication: Country unknown/Code not available
• Language: Russian

Related Subjects

AMINES
ANGULAR DISTRIBUTION
BIOLOGY AND MEDICINE
BLOOD FORMATION
BREMSSTRAHLUNG
CHROMOSOMES
COLLISIONS
COMPOUNDS
CROSS SECTIONS
CYTOLOGY
DENSITY
DIELECTRICS
DISTRIBUTION
EFFICIENCY
ELECTRONS
EMISSION
ENZYMES
FREQUENCY
IRRADIATION
LIGHT
MEA
MICE
MUTATIONS
ORGANIC SULFUR COMPOUNDS
POLARIZATION
QUANTITY RATIO
RADIATION DOSES
RADIATION INJURIES
RADIATION PROTECTION
RADIATIONS
SCATTERING
SURFACES
SURVIVAL TIME
TISSUES
TRANSIENTS
TRYPTAMINES
VACUUM
VARIATIONS
X RADIATION