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THE PROPHYLAXIS OF RADIATION SICKNESS IN MONKEYS BY MEANS OF 5- METHOXYTRYPTAMINE (in Russian)

Journal Article · · Radiobiologiya (U.S.S.R.) For English translation see Radiobiology (Engl. Transl.)
OSTI ID:4694136
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Severe radiation sickness was induced in monkeys by administering a gamma dose of 607 r. The radioprotective agent 5-methoxytryptamine was administered orally at a dosage of 250 mg/kg 30 minutes before the irradiation, and intramuscularly at a dosage of 25 mg/kg 10 minutes before the irradiation. All the controls died within 30 days with an average life of 9.2 days after showing severe symptoms of radiation sickness. The average life span was 17.3 days for the monkeys given intramuscular injection of the protective agent, and one out of seven monkeys was still living 30 days after the irradiation. Another monkey perished on the 30th day. Three out of eight monkeys, which had been given oral dose of the protective agent, were living on the 30th day after the irradiation. The average life-time was 14.0 days for this group. The appearance of bleeding, and the severity of leucopenia were less in the groups given a protective agent than they were in the controls. The protective agent 5- methoxytryptamine is more effective than tryptamine as a radioprotective agent. (TTT)

Research Organization:
Originating Research Org. not identified
NSA Number:
NSA-17-030425
OSTI ID:
4694136
Journal Information:
Radiobiologiya (U.S.S.R.) For English translation see Radiobiology (Engl. Transl.), Journal Name: Radiobiologiya (U.S.S.R.) For English translation see Radiobiology (Engl. Transl.) Vol. Vol: 3; ISSN RADOA
Country of Publication:
Country unknown/Code not available
Language:
Russian

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Related Subjects

ABSORPTION
AMINES
ATOMIC MODELS
ATOMS
BIOLOGY AND MEDICINE
CESIUM 133
COLLISIONS
COPPER SULFATES
COUPLING
CROSS SECTIONS
CRYSTALS
DENSITY
DIFFUSION LENGTH
EFFICIENCY
ERRORS
FREQUENCY
GAMMA RADIATION
HEMORRHAGE
INTERACTIONS
INTESTINE
LEUCOCYTES
MAGNETIC FIELDS
MAGNETISM
MEASURED VALUES
MONKEYS
MUSCLES
PARAMAGNETISM
QUANTITATIVE ANALYSIS
QUANTITY RATIO
RADIATION DOSES
RADIATION PROTECTION
RADIATION SICKNESS
RELAXATION
RESONANCE
RUBIDIUM 85
RUBIDIUM 87
SIGNALS
SPECTRA
SPIN
SURVIVAL TIME
TRYPTAMINES
VAPORS
VARIATIONS
WATER
ZEEMAN EFFECT