GRAFTS OF BONE MARROW AFTER WHOLE BODY IRRADIATION IN LEUKEMIC MICE FOLLOWING THE ADMINISTRATION OF AN ANTIMITOTIC TO REDUCE THE FREQUENCY OF THE SECOND SYNDROME AND TO ADD TO ANTILEUKEMIC EFFECT

Journal Article · Mon May 14 04:00:00 EDT 1962 · Compt. rend.

OSTI ID:4795341

Mathe, G; Amiel, J; Niemetz, J

In a study of the effect of bone marrow grafts on irradiated animals, hybrid mice F/sub 1/(C57 Bl/6 x DBA/2) received 10/sup 3/ cells of L 1210 leukemia and a radiation dose of 850 r. Animals treated wtth bone marrow grafts received 10/sup 7/ cells four hours after irradiation. Amethopterine and cyclophosphoamide at doses incapable of eradicating leukemia were used as antimitotics. The results tabulated show that the use of the antimitotic alone, as well as irradiation at a lethal dose followed by isogenic hematopoietic grafts, have a positive but weak antileukemic effect. Irradiation followed by semi-allogenic hematopoietic graft has a much sharper antileukemic effect, but animals died of the secondary syndrome. An attempt is made to interpret the results obtained in the case of animals receiving whole-body irradiation, bone marrow grafts, and antimitotic treatment. (J.S.R.)

• Research Organization: Hopital Saint-Louis, Paris; and Insitiut Gustave-Roussy, Villejuif, Seine, France
• NSA Number: NSA-16-026872
• OSTI ID: 4795341
• Journal Information: Compt. rend., Journal Name: Compt. rend. Vol. Vol: 254
• Country of Publication: Country unknown/Code not available
• Language: French

Related Subjects

BIOLOGY AND MEDICINE
BODY
BONE MARROW
CHEMICALS
ENDOXAN
LETHAL DOSE
LEUKEMIA
MICE
MITOSIS
ORGANIC CHLORINE COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
RADIATION DOSES
TRANSPLANTS