BONE MARROW GRAFTS AFTER TOTAL-BODY IRRADIATION OF LEUKEMIC MICE FOLLOWING THE ADMINISTRATION OF AN ANTIMITOTIC AGENT

Journal Article · Mon Jan 01 04:00:00 EST 1962 · Bulletin of the World Health Organization (U.S.)

OSTI ID:4734727

Mathe, G; Amiel, J L; Niemetz, J L

Attempts were made to determine whether pretreatment of irradiated, marrow-injected leukemic mice has a lifeprolonging effect. L 1210 leukemic cells, originally obtained from DBA/2 mice, were injected subcutaneously in F/sub 1/ hybrid mice (C57B16 x DBA/2). The mean survival time of the mice (11.0 days) was prolonged by treatment with the antimitotic agents amethopterin (21 days) and cyclophosphamide (15.5 days). Whole-body 850-rad x irradiation of the untreated leukemic mice slightly prolonged survival time (14.4 days), and this time was further prolonged by an injection of isologous (C57B16) bone marrow cells (22.6 days). Pretreatment of mice with the chemical agents, before irradiation and marrow replacement, significantly enhanced survival time. The effect was more pronounced with amethopterin (26.5 days) than cyclophosphamide (23.1 days). By combined use of marrow grafts and the antimiotic drugs it was possible to obtain prolonged survival (>70 days) of 9 out of 111 irradiated, leukemic mice. (H.H.D.)

• Research Organization: Hopital Saint Louis, Paris
• NSA Number: NSA-17-014019
• OSTI ID: 4734727
• Journal Information: Bulletin of the World Health Organization (U.S.), Journal Name: Bulletin of the World Health Organization (U.S.) Vol. Vol: 26; ISSN BWHOA
• Country of Publication: Country unknown/Code not available
• Language: French

Related Subjects

BIOLOGY AND MEDICINE
BODY
BONE MARROW
DRUGS
ENDOXAN
LEUKEMIA
MICE
MITOSIS
ORGANIC CHLORINE COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
RADIATION DOSES
SURVIVAL TIME
TRANSPLANTS
X RADIATION