INFLUENCE OF X IRRADIATION AND OF ISOLOGOUS AND HOMOLOGOUS RESTORATION ON SPONTANEOUS LEUKEMOGENESIS IN THE AKR STRAIN

Journal Article · Sun Jul 01 04:00:00 EDT 1962 · Nouvelle Rev. Franc. Hematol.

OSTI ID:4748325

Duplan, J F

Studies were conducted on the effect of whole-body irradiation on the incidence and latent period of leukemia in AKR mice. The incidence of lymphoid leukemia in unirradiated mice was 71% in males (latent period 302 days) and 82% in females (265 days). The 70-day-old mice were irradiated with 460, 600, or 800 r, which resulted in mortality rate of 0, 70, and 100%, respectively. Some mice were injected 16 to 20 hr postirradiation with isologous (AKR) or homologous (C/ sub 3/H and XVII) fetal liver or bone marrow cells. Injection of isologous liver cells did not change the incidence of leukemia, but in the 600-r group it prolonged the latent period. In the 460-r group, irradiation alone did not modify the appearance or incidence of leukemia, and in the survivors of the 600-r group the same negative results were obtained. Isologous bone marrow transplants in the 800-r group significantly reduced the incidence of leukemia (to 21% compared with 75% in controls). A similar reduction was also noted in the 460 and 600-r groups transplanted with homologous marrow cells. A study of the radiochimeras, which resulted, showed that successful transplantation of homologous cells was essential for inhibition of leukemogenesis. It is suggested that the grafted cells of homologous strains are less susceptible or completely insensitive to the leukemogenic virus. (H.H.D.)

• Research Organization: Institut du Radium, Paris
• NSA Number: NSA-17-015724
• OSTI ID: 4748325
• Journal Information: Nouvelle Rev. Franc. Hematol., Journal Name: Nouvelle Rev. Franc. Hematol. Vol. Vol: 2
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

AGE
BIOLOGY AND MEDICINE
BODY
BONE MARROW
CHIMERAS
FETUSES
IMMUNITY
LETHAL DOSE
LEUKEMIA
LIVER
LYMPHOCYTES
MICE
MORTALITY
QUANTITY RATIO
RADIATION DOSES
RADIATION EFFECTS
RADIATION INJURIES
RADIATION PROTECTION
SEX
TRANSPLANTS
VARIATIONS
VIRUSES
X RADIATION