ACTION OF ISOLOGOUS BONE MARROW FROM URETHAN-TREATED C57BL/6 MICE ON RADIATION LEUKEMOGENESIS

Journal Article · Sun Mar 01 04:00:00 EST 1964 · Journal of the National Cancer Institute (U.S.) Changed to JNCI, J. Natl. Cancer Inst.

OSTI ID:4068097

Berenblum, I; Boiato, L; Fiore-Donati, L; Trainin, N

Bone marrow cell suspensions from isologous mice pretreated with urethan were as effective in inhibiting radiation leukemogenesis in C57BL/6 mice as bone marrow from normal mice of the same strain. The results support earlier findings, by a different method of testing, from which it was concluded that the promoting effect of urethan in leukemogenesis did not depend on inactivation of the bone marrow. Females appeared to develop leukemia more readily than males in two groups of irradiated mice that were subsequently treated with bone marrow. The possible significance of this finding is discussed. (auth)

• Research Organization: Weizmann Inst. of Science, Rehovoth, Israel
• NSA Number: NSA-18-015899
• OSTI ID: 4068097
• Journal Information: Journal of the National Cancer Institute (U.S.) Changed to JNCI, J. Natl. Cancer Inst., Journal Name: Journal of the National Cancer Institute (U.S.) Changed to JNCI, J. Natl. Cancer Inst. Vol. Vol: 32; ISSN JNCIA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ANIMAL CELLS
BIOLOGY AND MEDICINE
BONE MARROW
CARBAMATES
CARCINOGENESIS
ETHYL RADICALS
LEUKEMIA
MICE
RADIATION EFFECTS
TOXICITY
TRANSPLANTS
URETHANE