FAILURE OF BONE MARROW TO INTERFERE WITH THE AUGMENTATION OF X-RAY LEUKEMOGENESIS BY URETHAN

Journal Article · Fri Dec 01 04:00:00 EST 1961 · Journal of the National Cancer Institute (U.S.) Changed to JNCI, J. Natl. Cancer Inst.

OSTI ID:4813067

Berenblum, I; Rewald, F E; Trainin, N

Ten weekly intravenous injections of isologous bone marrow into C57BL/6 mice, each injection following an intraperitoneal injection of urethan, failed to inhibit the augmentation by the urethan of leukemogenesis induced by a previous, single, total-body x irradiation of 400 r. One intravenous injection of bone marrow depressed leukemogenesis by a single dose of 400 r x irradiation without any urethan treatment. These results do not support the possibility that the urethan effect on leukemogenesis causes a depression of the bone marrow, and thus lend further weight to the idea that its action represents a promoting factor, with irradiation serving essentially as initiating factor, in the relatively low dose ranges used. When bone marrow was injected soon after the irradiation, to inhibit leukemogenesis, and urethan given subsequently, the resulting leukemia incidence was considerably higher than that obtained with irradiation alone, and almost as high as with irradiation, without bone marrow, followed by urethan. It is suggested that the inhibiting effect of normal bone marrow on x irradiation leukemogenesis probably operates at the initiating stage. (auth)

• Research Organization: Weizmann Inst. of Science, Rehovoth, Israel
• NSA Number: NSA-16-006332
• OSTI ID: 4813067
• Journal Information: Journal of the National Cancer Institute (U.S.) Changed to JNCI, J. Natl. Cancer Inst., Journal Name: Journal of the National Cancer Institute (U.S.) Changed to JNCI, J. Natl. Cancer Inst. Vol. Vol: 27; ISSN JNCIA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
BONE MARROW
CARBAMATES
CHEMICALS
ETHYL RADICALS
GRAFTS
LEUKEMIA
MICE
RADIATION DOSES
RADIATION INJURIES
TRANSPLANTS
URETHANE
X RADIATION