Marrow-thymus interactions during radiation leukemogenesis in C57BL/Ka mice
Journal Article
·
· Cancer Res.; (United States)
OSTI ID:6060506
Transplantation of thymus and bone marrow cells from irradiated C57BL/Ka mice demonstrated the presence of potentially neoplastic cells in the thymus at 30 to 60 days postirradiation. During the same interval, no such cells could be detected in the bone marow; moreover, the capacity of bone marrow cells to repopulate the thymus was impaired severely. These observations suggest that the primary site of neoplastic transformation in irradiated C57BL/Ka mice is the thymus rather than the bone marrow and that impaired thymic regeneration is a critical step in radiation leukemogenesis in mice.
- OSTI ID:
- 6060506
- Journal Information:
- Cancer Res.; (United States), Journal Name: Cancer Res.; (United States) Vol. 41:2; ISSN CNREA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BONE MARROW CELLS
CONNECTIVE TISSUE CELLS
DISEASES
DOSE-RESPONSE RELATIONSHIPS
HEMIC DISEASES
LEUKEMIA
MAMMALS
MICE
NEOPLASMS
ONCOGENIC TRANSFORMATIONS
RADIATION EFFECTS
RADIOINDUCTION
RODENTS
SOMATIC CELLS
THYMUS CELLS
TRANSPLANTS
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BONE MARROW CELLS
CONNECTIVE TISSUE CELLS
DISEASES
DOSE-RESPONSE RELATIONSHIPS
HEMIC DISEASES
LEUKEMIA
MAMMALS
MICE
NEOPLASMS
ONCOGENIC TRANSFORMATIONS
RADIATION EFFECTS
RADIOINDUCTION
RODENTS
SOMATIC CELLS
THYMUS CELLS
TRANSPLANTS
VERTEBRATES