Development of donor-derived thymic lymphomas after allogeneic bone marrow transplantation in AKR/J mice

Journal Article · Thu Sep 15 04:00:00 EDT 1988 · J. Immunol.; (United States)

OSTI ID:6557248

Yasumizu, R; Hiai, H; Sugiura, K; Oyaizu, N; Fan, H X; Ohnishi, Y; Iwai, H; Inaba, M; Kakinuma, M; Onoe, K

The transplantation of bone marrow cells from BALB/c (but not C57BL/6 and C3H/HeN) mice was observed to lead to the development of thymic lymphomas (leukemias) in AKR/J mice. Two leukemic cell lines, CAK1.3 and CAK4.4, were established from the primary culture of two thymic lymphoma, and surface phenotypes of these cell lines found to be H-2d and Thy-1.2+, indicating that these lymphoma cells are derived from BALB/c donor bone marrow cells. Further analyses of surface markers revealed that CAK1.3 is L3T4+ Lyt2+ IL2R-, whereas CAK4.4 is L3T4- Lyt2- IL2R+. Both CAK1.3 and CAK4.4 were transplantable into BALB/c but not AKR/J mice, further indicating that these cells are of BALB/c bone marrow donor origin. The cells were found to produce XC+-ecotropic viruses, but xenotropic and mink cell focus-forming viruses were undetectable. Inasmuch as thymic lymphomas are derived from bone marrow cells of leukemia-resistant BALB/c strain of mice under the allogeneic environment of leukemia-prone AKR/J mice, this animal model may serve as a useful tool not only for the analysis of leukemic relapse after bone marrow transplantation but also for elucidation of the mechanism of leukemogenesis.

• Research Organization: Kansai Medical Univ., Osaka (Japan)
• OSTI ID: 6557248
• Journal Information: J. Immunol.; (United States), Journal Name: J. Immunol.; (United States) Vol. 141:6; ISSN JOIMA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
ANIMALS
BIOLOGICAL MODELS
BODY
BONE MARROW
CHIMERAS
DISEASES
HEMATOPOIETIC SYSTEM
HEMIC DISEASES
IMMUNE SYSTEM DISEASES
LEUKEMIA
LYMPHATIC SYSTEM
LYMPHOMAS
MAMMALS
MICE
MICROORGANISMS
MOSAICISM
NEOPLASMS
ORGANS
PARASITES
PHENOTYPE
RADIATION CHIMERAS
RODENTS
THYMUS
TISSUES
TRANSPLANTS
VERTEBRATES
VIRUSES