STUDIES ON THE LYMPHOID TISSUE OF HEMATOLOGIC RADIOCHIMERAS
Journal Article
·
· Pathol. Biol. Semaine Hop.
OSTI ID:4718927
Repletion of lymphoid elements was studied in radiochimeras restored with immunologically compatible and incompatible hematopoietic cells. Repletion was rapid and complete in isogenic chimeras (F/sub 1/ C57B16 x DBA/2), which had been irradiated with 750 r and injected with bone marrow or a mixture of bone marrow and lymph node cells. However, restoration with allogenic cells (C57B16 irradiated mice injected with DBA/2 cells), when it resulted in repletion of myeloid elements, was followed by the secondary syndrome, with lymphopenia and lymphoid aplasia. Development of the syndrome was most rapid in animals receiving allogenic lymphoid cells. Studies with animals previously immunized with bacterial antigens showed that immunologic memory was retained in isogenic radiochimeras but lost in allogenic chimeras. Aplasia of the lymphoid tissue of the chimeras is thus the result of immunologic activity of the graft against the host, in addition to the irradiation injury of lymphoid cells. Pronounced restoration was obtained in F/sub 1/ hybrids irradiated and injected with marrow and lymph cells of the parental strains. Serum gamma -globulin levels are regenerated more rapidly in allogenic chimeras. However, a secondary hypogammaglobulinemia develops in the allogenic chimeras when the graft anti-host reaction destroys the lymphoid tissue. The incidence of the secondary syndrome after restoration with embryonic hematopoietic cells was as great as when the cells of adult incompatible donors were used. (TCO)
- Research Organization:
- Hopital Saint-Louis, Paris
- NSA Number:
- NSA-17-021543
- OSTI ID:
- 4718927
- Journal Information:
- Pathol. Biol. Semaine Hop., Journal Name: Pathol. Biol. Semaine Hop. Vol. Vol: 9
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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