Influence of Excess of Antigen on Immunological Tolerance in Radiation Chimæras

Journal Article · Sat Jan 19 04:00:00 EST 1963 · Nature (London)

DOI:https://doi.org/10.1038/197300a0· OSTI ID:4758055

ZAALBERG, O. B.; WEYZEN, W. W. H.; VOS, O.

When the lymphatic system of an irradiated allogenic animal is repopulated with cells from normal bone marrow, tolerance may only develop if sufficient antigens are present. Transplantation of even a small number of normal lymph node cells always results in an immunological graft versus host reaction and a killing effect'' of the host. Transfer of bone marrow from a tolerant chimaera to an irradiated animal in which the specific antigens are absent results in a loss of this tolerance, and when excess of another antigen is present, tolerance to this antigen may develop. A factor that determines the success of the transfer of tolerance is the dose of lymph node cells. Their number should be far in excess of the bone marrow cell dose. A competition to repopulate the lymphatic tissue seems to exist between bone marrow and lymphoid cells. These results indicate that mouse bone marrow is a source of cells with undetermined immunological function. These cells can develop into immunologically active lymphoid cells or into tolerant lymphoid cells when an antigen excess is present.

• Research Organization: National Defence Research Organization TNO, Rijswijk (Z.H.), Netherlands
• Sponsoring Organization: USDOE
• NSA Number: NSA-17-014053
• OSTI ID: 4758055
• Journal Information: Nature (London), Journal Name: Nature (London) Journal Issue: 4864 Vol. 197; ISSN 0028-0836
• Publisher: Nature Publishing Group
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
ANTIGENS
BONE MARROW
IMMUNITY
IRRADIATION
LYMPH NODES
LYMPH SYSTEM
MICE
QUANTITY RATIO
TRANSPLANTS