TRANSFORMATION OF HEMOPOIETIC CELLS OF TRANSPLANTED ALLOGENOUS BONE MARROW INTO IMMUNOLOGICALLY COMPETENT CELLS IN IRRADIATED DOGS

Journal Article · Sat Jun 01 04:00:00 EDT 1963 · Meditsinskaya Radiologiya (U.S.S.R.) For English translation see Med. Radiol., USSR

OSTI ID:4673484

Chertkov, I L; Novikova, M N; Rogacheva, L S; Shepshelevich, L L; Maksimenko, A S; Raushenbakh, M O

In experiments on dogs subjected to superlethal irradiation (1000 r), it was demonstrated that allogenous bone marrow transplantation does not produce a therapeutic effects inasmuch as normal hemopoiesis of the transplant is preserved only for 3--4 days. Starting from the 5th6th day there takes place transformation of hemopoietic cells into immunologically competent cells, which are the morphological basis of the transplant against host reaction. Transformation of hemopoietic cells (hemocytoblasts) into immunologically competent cells (lymphocytes) occurs via a number of transitional hyperbasophilic forms. of the type of peculiar hemocytoblast, lymphoblast, and prolymphocyte. The transformation of hemopoiesis is associated with the antigenic differences of the donor and recipient, since during repopulation of the bone marrow from the screened extremities in active proliferation no hyperbasophilic cells are formed and the myeloid hemopoiesis is preserved. The formation therefrom of hyperbasophilic cells and lymphocytes is due to transforination of hemocytoblasts and not immunologically coinpetent cells of the bone marrow, for this process was not as marked during transplantation of a suspension of lymphoid cells from the lymph nodes and spleen. (auth)

• Research Organization: Inst. of Hematology and Blood Transfusion, USSR
• NSA Number: NSA-17-031969
• OSTI ID: 4673484
• Journal Information: Meditsinskaya Radiologiya (U.S.S.R.) For English translation see Med. Radiol., USSR, Journal Name: Meditsinskaya Radiologiya (U.S.S.R.) For English translation see Med. Radiol., USSR Vol. Vol: 8: No. 6; ISSN MERAA
• Country of Publication: Country unknown/Code not available
• Language: Russian

Related Subjects

ANTIGENS
BIOLOGY AND MEDICINE
BLOOD FORMATION
BONE MARROW
CYTOLOGY
DOGS
EFFICIENCY
IMMUNITY
LETHAL DOSE
LYMPH NODES
LYMPH SYSTEM
LYMPHOCYTES
MEDICINE
RADIATION DOSES
SPLEEN
SUSPENSIONS
THERAPY
TRANSPLANTS