THE INTENSITY OF PHOSPHOLIPID EXCHANGE IN THE CENTRAL NERVOUS SYSTEM OF THE RAT DURING SEVERE RADIATION SICKNESS (in Russian)
White Wistar rats were given an x-ray dose of 750 r. The rate of phospholipid exchange was determined by giving the rats 0.5 mu C of P/sup 32/ per gram of body weight as Na/sub 2/HP/sup 32/ O/sub 4/ at 2, 4, 6, 12, 24, 48, 72 and 96 hours after the irradlation. The rats were beheaded cxactly I20 minutes after administration of the P/sup 32/. The ratio of the speclfic activity of the phosphollpid fraction to the specific activity of the inorganic phosphate (termed the RSA) was taken as a measure of the rate of exchange. In the controls the RSA was found to be 1.91 for the braln, 0.81 for the spinal cord, 9.81 for the liver, and 2.32 for the spleen. The RSA rose slightly in the first two hours after irradiation for all tissues as compared to the controls. Then, the RSA of the brain and of the spinal cord decreased, rose to normal, and only on the 3rd and 4th day, decreased significantly again. The RSA for the liver showed a similar behavior. The RSA for the spleen remained slightly above normal, decreased sharply at 72 hours after irradiation, and then rose sharply above normal at 96 hours after irradiation. These changes can be related to physiological changes caused by radlation sickness. It is concluded that a dose of 750 r does not cause direct damage to the biological systems responsible for the synthesis of phospholipids in the central nervous system, the liver and the spleen. (TTT)
- Research Organization:
- Pavlova Inst. of Physiology, Academy of Sciences, USSR
- NSA Number:
- NSA-16-014588
- OSTI ID:
- 4795265
- Journal Information:
- Doklady Akad. Nauk S.S.S.R., Journal Name: Doklady Akad. Nauk S.S.S.R. Vol. Vol: 142
- Country of Publication:
- Country unknown/Code not available
- Language:
- Russian
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