Effects of X-Irradiation on Phospholipid Metabolism: I. Investigation of P³² Uptake into Individual Liver and Spleen Phosphatides of Normal and Irradiated Mice

Journal Article · Fri Nov 30 23:00:00 EST 1962 · Radiation Res.

DOI:https://doi.org/10.2307/3571321· OSTI ID:4771615

Lee, T C; Salmon, R J; Loken, M K; Mosser, D G

Phospholipids, tagged with P³², of liver and spleen of normal and irradiated mice were separated by silicic acid column chromatography. The speciiic radioactivity of the total phospholipids and of seven groups of phosphatides was determined at various times after the injection of the P³² in both normal and irradiated animals. The uptake of P³² into the total liver phospholipids was higher in the irradiated animals than in the controls. This was due to increased specific activity of the cephalins and lecithins. The specific activity of inositides and lysolecithin was not greatly changed by irradiation, whereas that of the sphingomyelins was increased at 2 and 4 hours but decreased after 8 hours. The specific radioactivity of liver phospholipids reached a maximum at 8 hours after injection of the P³² in normal animals but occurred at 6 hours in the irradiated animals.

• Research Organization: Univ. of Minnesota, Minneapolis
• Sponsoring Organization: USDOE
• NSA Number: NSA-17-004419
• OSTI ID: 4771615
• Journal Information: Radiation Res., Journal Name: Radiation Res. Vol. Vol: 17
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
CEPHALINS
CHROMATOGRAPHY
CONFIGURATION
IONIZATION
LECITHINS
LIPIDS
LIVER
MEASURED VALUES
METABOLISM
MICE
MODERATORS
NEUTRON DETECTION
ORGANIC PHOSPHORUS COMPOUNDS
PHOSPHOLIPIDS
PHOSPHORUS 32
RADIATION DETECTORS
RADIATION EFFECTS
RADIOACTIVITY
SENSITIVITY
SPLEEN
TRACER TECHNIQUES
X RADIATION