THE EFFECT OF IONIZING RADIATION ON THE PHOSPHOLIPID METABOLISM IN THE LIVER

Journal Article · Tue Nov 01 04:00:00 EST 1960 · Biochemistry (U.S.S.R.)(English Translation)

OSTI ID:4094837

Kainova, A S

The total phospholipid content in rat liver does not change during the first duy following irradiation by a 1000 r of gamma rays. In rabbits, on the other hand, the liver phospholipids immediately drop 25% subsequent to irradiation of not more than 5000 r. In rat liver, the lecithin fraction of the phospholipids increases 33.7% within 24 hours following irradiation, the sphingomyelin fraction increasing under the same conditions 41.6%, while the cephalin fraction decreases by 56.6%. In rabbits, the lecithin fraction of the liver phospholipids rises 13.4% immediately following irradiation by 5000 r, the sphingomyelin fraction rising 66.5%, while the cephalin fraction drops 34.7%. The general intensity of the phospholipid metabolism in rat liver increases within 24 hours following irradiation with a 1000 r dose. Within two and four hours the relative specific radioactivity of phospholipids increases 100%, within six hours, it increases 137%, and within 24 hours, 42%. The incorporation of labeled phosphate into the liver sphingomyelins increases particularly in the 24 hours following irradiation; the relative specific radioactivity of this fraction is 262.5% above the control. (auth)

• Research Organization: Originating Research Org. not identified
• NSA Number: NSA-15-010703
• OSTI ID: 4094837
• Journal Information: Biochemistry (U.S.S.R.)(English Translation), Journal Name: Biochemistry (U.S.S.R.)(English Translation) Vol. Vol: 25
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
GAMMA RADIATION
LIPIDS
LIVER
METABOLISM
PHOSPHORUS COMPOUNDS
PROTEINS
RABBITS
RADIATION EFFECTS
RADIOACTIVITY
RATS