ACTION OF X RAYS ON BILIRUBIN

Journal Article · Wed Feb 01 04:00:00 EST 1961 · Arch. Intern. Physiol. Biochim.

OSTI ID:4789846

Barac, G; Beaumariage, M; Cuvelier, C; Notay, W

A study was made of whether bilirubin is oxidized by the free radicals forming during the radiolysis of water containing this pigment, and, if so, whether this can be prevented by radioprotective substances. Bilirubin solutions of various concentrations of pH 5.8, 7.35, or 13,3 were irradiated at a rate of 236 r/sec, In solutions containing 10 mg/l the pigment was destroyed at doses above 5000 r and this was 98% complete at 100,000 r. Similar results were obtained at all 3 pH values. The following substances protected bilirubin, some of them at concentrations as low as 0.001M; ascorbic acid, cysteine, cystine, e rgothionine, 5-hydroxytryptamine, propylthiouracil, methylthiouracil, thiouracil, tryptamine, cysteamine, cystamine, 5-hydroxyindoleacetic acid, thiosalicylic acid, and thioacetamide. Thiourea, urea, and glucose were ineffecttve at 1000- fold higher concentrations. Most of the compounds affording radioprotection to bilirubin contain labile H atoms. Radio-oxidation of btlirubin does not give rise to btliverdin, but probably to a product similar to that formed by direct oxygenation, (H.H.D.)

• Research Organization: Universite, Liege
• NSA Number: NSA-17-001184
• OSTI ID: 4789846
• Journal Information: Arch. Intern. Physiol. Biochim., Journal Name: Arch. Intern. Physiol. Biochim. Vol. Vol: 69
• Country of Publication: Country unknown/Code not available
• Language: French

Related Subjects

ACIDITY
AMINES
AMINO ACIDS
ATOMS
BILIRUBIN
BILIVERDIN
BIOLOGY AND MEDICINE
BLOOD SERUM
CYSTAMINE
CYSTEAMINE
CYSTEINE
DRUGS
FREE RADICALS
GLUCOSE
HYDROGEN
ORGANIC SULFUR COMPOUNDS
OXIDATION
PIGMENTS
QUANTITY RATIO
RADIATION DOSES
RADIATION EFFECTS
RADIATION PROTECTION
RADIOCHEMISTRY
SALICYLIC ACID
SUGARS
THIOURACIL
TRYPTAMINES
UREA
VITAMIN C
VITAMINS
WATER
X RADIATION