NEW RESULTS ON THE IRRADIATION OF BILIRUBIN BY MEANS OF X RAYS

Journal Article · Fri Sep 01 04:00:00 EDT 1961 · Arch. Intern. Physiol. Biochim.

OSTI ID:4767987

Beaumariage, M; Barac, G

Various radioprotective agents were tested in irradiated aqueous solutions of bilirubin and its glucuronide derivatives. Hydroxhndoleacetic acid protects the pigment from oxidation but indoleacetic acid does not, showing the importance of the hydroxyl group, which may provide labile H. Dehydroascorbic acid is as protective as cystine and cystamine, these 3 compounds lack labile H atoms and their mode of action is not readily explainable. Ovalbumin, which does not bind bilirubin or its glucuronides, is not radioprotective at a concentration of 50 g/l. Peroxidase and catalase are inactive, which suggests that the radiation-generated oxidizing agent is not oxygen. Bilirubin in acetone or chloroform solution is strongly oxidized by irradiation and to a much less extent in ethanol solution. Irradiation of chloroform alone causes the formation of peroxides which can oxidize bilirubin, and the presence of alpha -tocopherol inhibits the oxidation of bilirubin in organic solvents. Irradiation of the dry pigment does not affect it. (H.H.D.)

• Research Organization: Universite, Liege
• NSA Number: NSA-17-001186
• OSTI ID: 4767987
• Journal Information: Arch. Intern. Physiol. Biochim., Journal Name: Arch. Intern. Physiol. Biochim. Vol. Vol: 69
• Country of Publication: Country unknown/Code not available
• Language: French

Related Subjects

ACETIC ACID
ACETONE
ALBUMINS
AMINO ACIDS
ATOMS
BILIRUBIN
BIOLOGY AND MEDICINE
CHLORINATED HYDROCARBONS
CHLOROFORM
CYSTAMINE
CYSTEINE
ENZYMES
ETHANOL
GLUCURONIC ACID
HYDROGEN
HYDROGEN PEROXIDES
INDOLES
METABOLISM
ORGANIC ACIDS
ORGANIC NITROGEN COMPOUNDS
OXIDATION
OXYGEN
PEROXIDASES
PIGMENTS
QUANTITY RATIO
RADIATION EFFECTS
RADIATION PROTECTION
SOLUTIONS
VITAMIN K
VITAMINS
X RADIATION