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COBALT THERAPY AND PLASMA PROTEINS IN CANCER PATIENTS

Journal Article · · Bull. Assoc. Franc. Etudes Cancer
OSTI ID:4789138

Changes in plasma protein fractions are described in 100 patients whose tumors were irradiated with Co/sup 60/ These fractions were determined before, at the midpoint of therapy (after 3000 to 5000 r), and following completion of therapy (after 6000 to 12,000 r). The most pronounced change before treatment was the increase in alpha -globulin and in glycoproteins, especially the alpha fraction. Albumin was diminished in the cancer patients beiore therapy. After treatment an improvement in the plasma protein pattern was noted in most cases, including a rise in albumin and a fall in alpha -globulins and glycoproteins. Irradiation had no significant effect on BETA - and gamma -globulins. The fall in alpha glycoproteins occurred more rapidly than that of alpha -globulins in general. The resorcinol index of Verne, which was initially elevated, fell after treatment but more slowly than alpha -glubolins. It is suggested that the plasma protein pattern changes after radiation therapy may have diagnostic and prognostic significance. (H.H.D.)

Research Organization:
Centre Regional Anticancereux, Toulouse
NSA Number:
NSA-17-001275
OSTI ID:
4789138
Journal Information:
Bull. Assoc. Franc. Etudes Cancer, Journal Name: Bull. Assoc. Franc. Etudes Cancer Vol. Vol: 48
Country of Publication:
Country unknown/Code not available
Language:
English