STUDY OF THE CHANGES IN LYMPHOCYTE POLYSACCHARIDES AND SERUM GLYCOPROTEINS IN PATIENTS SUBJECTED TO ROENTGEN THERAPY
Studies were conducted on 10 patients with pulmonary and mammary cancer, Hodgkin's disease, or leukemia who were recovering from 200-kv x-ray therapy (single daily doses of 100 to 200 r andtotal doses of 1100 to 15000 r). Lymphocyte polysaccharide content was determined in peripheral cells by the periodic acid-Schiff histochemical techninue, and serum glycoprotein were examined electrophoretically in paper strips stained by the same reaction. Circulating lymphocyte counts fell in all patients to levels 30 to 50% below pretreatment values. This was accompanied by a 150 to 200% rise in the polysaccharide content of the cytoplasm of individual cells. The material was only partly digested by takadiastase, showing that it is not glyconsistent but, in general, glycoprotein content tended to be increased by irradiation in the alpha /sub 1/- and gamma ,-globulin fractions and decresed in the albumin and alpha /sub 2/- and BETA -globulin fractions. Neither the polysaccharide changes in lymphocytes nor the glycoprotein changes in serum could be correlated with the radiation dose. The finding in lymphocytes suggest that radiation may have stimulated cytoplasmic metabolic function in surviving or regenerite cells. (H.H.D.)
- Research Organization:
- Universita, Pavia, Italy
- NSA Number:
- NSA-17-014007
- OSTI ID:
- 4749987
- Journal Information:
- Boll. Soc. Ital. Biol. Sper., Journal Name: Boll. Soc. Ital. Biol. Sper. Vol. Vol: 37
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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