ATTEMPT AT RADIOPROTECTION OF MICE WITH TWO DERIVATIVES OF ANILINE

Journal Article · Wed Feb 01 04:00:00 EST 1961 · Arch. Intern. Physiol. Biochim.

OSTI ID:4788440

Beaumariage, M L; Liebecq-Hutter, S; Freire, S A

Since aniline was previously found to protect mice against lethal doses of radiation, 2 derivatives (p-chloroethylaniline and diethylaminoethyl-p- chloroantline) was synthesized and tested in C57 mice irradiated at a rate of 100 r/min. The 1st compound (50 mg/kg) injected 20 min before exposure to 590 r protected 75% of the mice whereas 86 to l00% of the uninjected mice died within 12 days. It was less effective when injected 2 or 10 min before irradiation. It was not effective after 800 r, all mice dying even when injected with 100 mg/kg. The lower dose was somewhat toxic in mice; it produced adynamia, hypertension, hypothermia, and cyanosis of mucosae and paws within 20 to 40 min. Methemoglobinemia was apparent within 5 min. When the 2nd compound (72.5 mg/kg) was injected 20 min before 590 r, 33% of the mice survived; at double this dose, survival decreased to 17%. It was more toxic than the 1st compound and, as the results show, offered less protection. Protection with the first compound is apparently explained by the methemoglobinemia and hypothermia it induces, the resulting anoxia reducing the injury caused by radiation. (H.H.D.)

• Research Organization: Universite, Liege
• NSA Number: NSA-17-001343
• OSTI ID: 4788440
• Journal Information: Arch. Intern. Physiol. Biochim., Journal Name: Arch. Intern. Physiol. Biochim. Vol. Vol: 69
• Country of Publication: Country unknown/Code not available
• Language: French

Related Subjects

AMINES
ANILINE
BIOLOGY AND MEDICINE
BLOOD CIRCULATION
BLOOD VESSELS
BODY
DISEASES
HEMOGLOBIN
HYPERTENSION
HYPOTHERMIA
METHEMOGLOBIN
MICE
MUSCLES
ORGANIC NITROGEN COMPOUNDS
OXYGEN
PHENYL RADICALS
QUANTITY RATIO
RADIATION DOSES
RADIATION EFFECTS
RADIATION INJURIES
RADIATION PROTECTION
TEMPERATURE
TOXICITY