Mechanism of the Protective Action of 2-mercaptoethylguanidine (MEG) against Whole-body Radiation in Mice
Journal Article
·
· International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine
Two-mercaptoethylguanidine will protect mice against the lethal effects of an x-ray exposure of 900 r, converting an LD100 in 13 days to an LD10 in 30 days. Body weight, spleen, thymus, and small-intestine weight, total whitecell count and total marrow count (right femur) are identical for at least the first 48 hours post-exposure in mice given 900 r, whether treated with MEG or not. Of the parameters studded only the marrow count and small intestine weight show definite recovery by the fifth day in MEG-treated mice; all others recover during the second post-exposure week. The evidence presented indicates that MEG- treated mice recover faster without lessening the initial damage due to radiation. A dose-reduction of about 2 was found, based on the known 30-day lethality of this strain of mouse.
- Research Organization:
- Walter Reed Army Inst. of Research, Washington, D.C.
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-16-012938
- OSTI ID:
- 4786947
- Journal Information:
- International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine, Journal Name: International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine Journal Issue: 1 Vol. 4; ISSN 0020-7616
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
Similar Records
THE DISTRIBUTION AND METABOLISM OF ORALLY ADMINISTERED 2- MERCAPTOETHYLGUANIDINE (MEG) AND BIS(2-GUANIDOETHYL) DISULFIDE (GED) IN PROTECTED MICE
PROTECTIVE EFFECT OF MEG ON RADIATION INJURIES OF HEMATOPOIETIC SYSTEM IN MICE AND RATS
The Mechanism of Action of AET: V. The Distribution and the Chemical Forms of 2-Mercaptoethylguanidine and Bis(2-Guanidoethyl) Disulfide Given Orally in Protective Doses to Mice
Journal Article
·
Mon Mar 30 23:00:00 EST 1964
· Annals of the New York Academy of Sciences (U.S.)
·
OSTI ID:4016676
PROTECTIVE EFFECT OF MEG ON RADIATION INJURIES OF HEMATOPOIETIC SYSTEM IN MICE AND RATS
Journal Article
·
Thu Aug 01 00:00:00 EDT 1963
· Nippon Igaku Hoshasen Gakkai Zasshi (Japan)
·
OSTI ID:4104197
The Mechanism of Action of AET: V. The Distribution and the Chemical Forms of 2-Mercaptoethylguanidine and Bis(2-Guanidoethyl) Disulfide Given Orally in Protective Doses to Mice
Journal Article
·
Sun Sep 01 00:00:00 EDT 1963
· Radiation Research
·
OSTI ID:4636170