The Mechanism of Action of AET: V. The Distribution and the Chemical Forms of 2-Mercaptoethylguanidine and Bis(2-Guanidoethyl) Disulfide Given Orally in Protective Doses to Mice

Journal Article · Sun Sep 01 00:00:00 EDT 1963 · Radiation Research

DOI:https://doi.org/10.2307/3571326· OSTI ID:4636170

Kollmann, George; Shapiro, Bernard; Schwartz, Emanuel E.

The distribution and chemical forms of 2-mercaptoethylguanidine (MEG) and bis(2-guanidoethyl) disulfide (GED) in the various tissues or 8- to 10-week- old C57Bl male mice 30 min after an oral radiation protective dose of 400 mg of MEG-S³⁵ and GED-S³⁵/kg were studied. At 30 min after oral administration of MEG or GED, a significant amount of protective agent remained in the gastrointestinal tract. This accounts for some of the differences in LD₅₀(30) values for equal doses of protective agent by oral and intraperitoneal routes. MEG was absorbed from the intestines more rapidly than GED, and protective forms appeared in the tissues in higher concentration after MEG administration. This explains the better protection provided by oral MEG as compared with oral GED at 30 min. The difference in absorption rates of MEG and GED may be useful in controlling the speed of onset and duration of protection by these agents in mice.

• Research Organization: Albert Einstein Medical Center, Philadelphia
• Sponsoring Organization: USDOE
• NSA Number: NSA-17-040509
• OSTI ID: 4636170
• Journal Information: Radiation Research, Journal Name: Radiation Research Journal Issue: 1 Vol. 20; ISSN 0033-7587
• Publisher: Radiation Research Society
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
AET
AGE
BIOCHEMISTRY
DIFFUSION
DISTRIBUTION
DRUGS
EFFICIENCY
INTESTINE
LABELLED COMPOUNDS
LETHAL DOSE
MEG
MICE
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
QUALITATIVE ANALYSIS
RADIATION EFFECTS
RADIATION PROTECTION
RADIOACTIVITY
STOMACH
SULFUR 35
TESTING
TISSUES
TRACER TECHNIQUES
VARIATIONS