THE DISTRIBUTION AND METABOLISM OF 2-MERCAPTOETHYLGUANIDINE AND BIS(2- GUANIDOETHYL) DISULFIDE IN MICE
Issued by School of Aviation Medicine, Brooks AFB, Tex. Various doses of MEG-S/sup 3//sup 5/ and GED-S/sup 3//sup 5/ were administered by oral and intraperitoneal routes to 8- to 10-week old C57BL/6J mice. The distribution of S/ sup 3//sup 5/ in the tissues of the animals was determined at various times. The metabolic forms of S/sup 3//sup 5/ in the tissues of the animals were isolated and partially identified. It was found that S/sup 3//sup 5/ concentrations were lowest in bone marrow and brain and highest in liver and kidney. Increasing doses of MEG-S/sup 3//sup 5/ and GED-S/sup 3//sup 5/ generally resulted in increasing tissue S/sup 3//sup 5/ concentrations. After oral administration of the protective agent, as much as one-third of the administered dose was found in the gastrointestinal tract. This explained the need to use much larger doses for protection by oral administration of MEG or GED. More than half of the S/sup 3// sup 5/ in the animal was in the protein-bound form. No other form was seen consistently in all tissues studied. It was suggested that the proteinbound form may be the protective form of MEG and GED. (auth)
- Research Organization:
- Albert Einstein Medical Center. Radiology Dept., Philadelphia
- NSA Number:
- NSA-15-017902
- OSTI ID:
- 4013539
- Report Number(s):
- AF-SAM-61-52
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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