FURTHER STUDIES ON THE DISTRIBUTION AND METABOLISM OF 2- MERCAPTOETHYLGUANIDINE AND BIS(2-GUANIDOETHYL) DISULFIDE IN MICE
The distribution and chemical forms of S/sup 35/-labeled MEG and GED in the tissues of protected C57BL male mice were studied. Results were obtained at 20 minutes after intraperitoneal injection of 140 and 280 mg/kg MEG and at 20, 80, and 120 minutes after intraperitoneal injection of 140 mg/kg GED. Protein- bound S/sup 35/, GED, taurocyamine, guanidoethame sulfinic acid, MEG, and sulfate were identified in the tissues. Protein-bound S/sup 35/ and GED decreased at 120 minutes and correlated best with protectton of the mice. All other products increased or were unchanged at 120 minutes. These results suggest that one or both of these forms is directly involved in radiation protection. (auth)
- Research Organization:
- Albert Einstein Medical Center. Radiology Dept., Philadelphia
- NSA Number:
- NSA-17-005908
- OSTI ID:
- 4753494
- Report Number(s):
- SAM-TDR-62-68
- Country of Publication:
- United States
- Language:
- English
Similar Records
THE DISTRIBUTION AND THE CHEMICAL FORMS OF THE RADIATION-PROTECTIVE AGENT AET IN LEUKEMIC MICE
The Mechanism of Action of AET: V. The Distribution and the Chemical Forms of 2-Mercaptoethylguanidine and Bis(2-Guanidoethyl) Disulfide Given Orally in Protective Doses to Mice