THE MECHANISM OF ACTION OF AET. IV. THE DISTRIBUTION AND THE CHEMICAL FORMS OF 2-MERCAPTOETHYLGUANIDINE AND BIS(2-QUANIDOETHYL) DISULFIDE IN PROTECTED MICE
The distribution and chemical nature of the protective agent in the various tissues of 8- to 10-week-old C57BL/6J male mice given a protective dose of MEG-S/sup 35/ and GEDS/sup 35/ were studied. Results were obtained at 20 minutes after an intraperitoneal (i.p.) injection of 140 and 280 mg of MEG per kilogram and at 20, 60, and 120 min after an i.p, injection of 140 mg of GED per kilogram. Protein-bound S/sup 35/, GED, taurocyamine, guanidoethanesulfinic acid, MEG, and sulfate were identified in the serum, tissues, and excreta. Several unknown compounds were also observed. Concentrations of protein-bound S/ sup 35/ and GED decreased at 120 minutes after GED administration and correlated best with protection of the mice. All products increased in the tissues at the higher dose of MEG. Some differences in the concentrations of products were noted on comparison of MEG with GED-treated animals. The relation of the results to the mechanisms of action of MEG and GED is discussed. (auth)
- Research Organization:
- Albert Einstein Medical Center, Philadelphia
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-17-023066
- OSTI ID:
- 4712733
- Journal Information:
- Radiation Res., Journal Name: Radiation Res. Vol. Vol: 18
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
Similar Records
THE DISTRIBUTION AND THE CHEMICAL FORMS OF THE RADIATION-PROTECTIVE AGENT AET IN LEUKEMIC MICE
THE DISTRIBUTION AND THE CHEMICAL FORMS OF THE RADIATION-PROTECTIVE AGENT AET IN MAMMARY TUMOR-BEARING MICE