ENDOCRINE GLANDS AND SECRETION OF I$sup 131$ BY THE SUBMAXILLARY GLAND OF C3H MICE
Journal Article
·
· Acta Physiologica Latinoamericana (Argentina)
OSTI ID:4777190
Effects of castration, adrenalectomy, and administration of testosterone, estradiol, corticosterone, and aldosterone on the concentration of I/sup 131/ by the submaxillary gland of male and female C3H mice were studied. The ratio between I/sup 131/ per mg of submaxillary gland and I/sup 131/ per mg of blood (SM/B ratio) was taken as an index of the submaxillary gland's ability to concentrate I. Castration increased the SM/B ratio in males but did not modify it in females, so that in castrated animals the sexual difference in the ratio became more evident. Administration of testosterone to castrated males restored the changes induced by castration. Estradiol in castrated females diminished the SM/B ratio in proportion to the dose. Adrenalectomy in both sexes increased the SM/B ratio. In adrenalectomized animals, corticosterone diminished the ratio to the normal value and aldosterone had no action. Corticosterone in normal mice diminished the uptake by the submaxillary gland in males and increased it in females. Aldosterone raised the SM/B ratio in both sexes. These changes may occur through 2 mechanisms: (1) structural modification of the submaxillary gland, and (2) functional alteration, mainly in salivary secretlon. (H.H.D.)
- Research Organization:
- Inst. of Experimental Biology and Medicine, Buenos Aires
- NSA Number:
- NSA-17-001203
- OSTI ID:
- 4777190
- Journal Information:
- Acta Physiologica Latinoamericana (Argentina), Journal Name: Acta Physiologica Latinoamericana (Argentina) Vol. Vol: 11; ISSN APLTA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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