EFFECTS OF RADIOSTRONTIUM ON THE BLOOD AND HAEMATOPOIETIC TISSUES OF MICE
The effects of radiostrontium on the blood and hematopoietic tissues were studied in 200 CBA mice injected intraperitoneally with 0.67 mu C Sr/sup 90/ per g body weight. Groups of 10 mice given Sr/sup 90/ and 10 control mice were killed at fixed intervals after the injection of Sr/sup 90/. Total leukocyte counts, differential counts, thrombocyte counts, and hemoglobin determinations were made. The spleen and bone marrow in the femur, tibia, humerus, and thoracic and lumbar vertebrae were examined histologically. Bone marrow damage including severe hypoplasia, dilatation of sinusoids, and an increase in fatty tissue, were observed in all bones examined. Damage was more severe in the femur and tibia than in the humerus and vertebrae. The site of marrow damage corresponded fairly well with the distribution pattern for Sr/sup 90/ and the temporal changes in this pattern. Shortly after the injection of Sr/sup 90/, damage was most severe in the distal metaphyseal region of the femur and in the proximal metaPhysis of the tibia and humerus. Later, the most severe changes were in the diaphyses of the long bones and regeneration gradually occurred proximally and distally in the long bones immediately adjacent to the epiphyseal plates. Close to the areas of regeneration, marrow damage was usually more persistent and more severe than in other regions with the exception of the initial damage in the metaphysis. Most tumors arise in this site. There was an initial and significant leukocytosis which, by 24 hours, gave way to a leukopenia. Leukopenia then persisted throughout the experimental period (10 months). Hemoglobin levels fell up to the 16th day but from the second month onwards hovered about normal values. The drop in thrombocyte counts was not accompanied by a propensity to hemorrhage. The spleen increased greatly in weight, principally because of great increase in erythro- and megakaryocytopoiesis. (28 references.) (auth)
- Research Organization:
- Research Inst. of National Defence, Sundbyberg, Sweden
- NSA Number:
- NSA-16-031479
- OSTI ID:
- 4776946
- Journal Information:
- Acta Veterinaria Scandinavica (Denmark), Journal Name: Acta Veterinaria Scandinavica (Denmark) Vol. Vol: 3; ISSN AVSCA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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