Comparative study on the response of the reticular tissue to the administration of radiostrontium ($sup 90$Sr) and total-body x-irradiation in mice. An investigation on the comparative histogenesis of radiation-induced leukemogenesis (in Japanese)
Female ICR/JCL mice were injected intraperitoneally with 1.0 microcurie/ g of /sup 90/Sr. The hematological, patho-histological, cytogenetic, and radiological findings of these mice were compared with those in mice exposed to fractionated total-body x-irradiation of 680R (4 times at 170R each, at a 5 day interval). A drastic leukopenia caused by total-body x-irradiation was followed by a smooth recovery whereas leukopenia developed following /sup 90/Sr injection was relatively mild, appeared more slowly, and lasted for a longer period, Total- body x-irradiation provoked injuries both in granulopoiesis and lymphopoiesis whereas /sup 90/Sr gave rather selective damage in the granulopoiesis. The changes in the weight of lymphoid tissues following total-body x-irradiation was uniform, reflecting the homogeneous damage in the tissues whereas the weight change was negligible in /sup 90/Sr-injected mice except the weight loss of lymph nodes on and after 60th day of injection. In x-irradiated mice, a vigorous regenerating process in the medullary and extramedullary hematopoiesis took place a few days after the last exposure. The regeneration in the peripheral lymphoid tissues was apparently slower than that in the thymus, indicating the dependence of the lymphoid tissue upon the thymic function. A long lasting medullary hypoplasia and the skeletal hyperplasia were the only characteristic findings in / sup 90/Sr-injected mice. In x-irradiated mice, a small focus of atypical cells with many mitotic figures was found in the deep cortex of an atrophic lobe of the thymus as early as 30 days after treatment. In /sup 90/Sr-injected mice, appreciable histological changes were confined within the bone marrow up to 60 days after injection. Cytogenetic studies revealed that, in x-irradiated mice, an increase in the aberrant cell population in the thymus on and after 60th day of treatment was preceded by an abrupt increase in the chromosomally aberrant cells in the bone marrow shortly after the treatment. The estimation of the residual radioactivity in various tissues after /sup 90/Sr injection indicated that a sustained hypoplasia of the medullary hematopoiesis was induced by the selective and prolonged deposit of the isotope in the skeleton. (auth)
- Research Organization:
- Hiroshima Univ.
- NSA Number:
- NSA-29-015998
- OSTI ID:
- 4342005
- Journal Information:
- Med. J. Hiroshima Univ., v. 21, no. 1-2, pp. 61-92, Journal Name: Med. J. Hiroshima Univ., v. 21, no. 1-2, pp. 61-92; ISSN HDIZA
- Country of Publication:
- Japan
- Language:
- Japanese
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N48520* --Life Sciences--Radiation Effects on Animals-- Vertebrates
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PHOTON BEAMS
SKELETON
UPTAKE
WHOLE-BODY IRRADIATION
X RADIATION