Studies on the leukemogenic and immunologic effects of radiostrontium ($sup 90$Sr) and x rays in mice

Conference · Thu Jan 01 04:00:00 EST 1976

OSTI ID:4062044

Ito, K; Nagao, K; Kawamura, Y; Yokoro, K

The leukemogenic effect of internal irradiation with radiostrontium ($sup 90$Sr) was compared with that of external irradiation with x rays in ICR/ JCL mice. Immunological, hematological, and cytogenetical changes were also studied during the preleukemic period in mice treated with $sup 90$Sr or with x rays. A single intraperitoneal injection of 1.0 $mu$Ci of $sup 90$Sr per gram of body weight resulted in leukemia in 62 percent of the mice. Only one of the $sup 90$Sr-induced leukemias was of thymic origin. The occurrence of the leukemia was not affected by thymectomy. A fractionated whole-body x-irradiation of 680 R induced leukemia in 77 percent of the mice; the majority of the leukemias were of thymic origin. Although x-irradiation over the thymic region was ineffective in eliciting leukemia, a combined treatment of $sup 90$Sr and local x-irradiation of the thymus was effective in inducing thymic lymphomas. The single intraperitoneal administration of $sup 90$Sr caused an enhancement of both direct and indirect splenic plaque-forming cell (PFC) responses to sheep red blood cells, lasting for 35 days after treatment. No changes were observed in delayed- type hypersensitivity to picryl chloride. Thymectomy caused no appreciable effect in these immune responses. The fractionated whole-body x-irradiation rapidly depressed both PFC and delayed-type hypersensitivity responses, which persisted for a long period, especially in thymectomized mice. An abrupt increase of chromosomally aberrant cells in the thymus 60 days after the last x- irradiation was preceded by an increase of aberrant population in the bone marrow. On the other hand, a long-lasting appearance of aberrant population in the bone marrow and lymph nodes was observed in $sup 90$Sr-injected mice. (auth)

• Research Organization: Hiroshima Univ.; Battelle Pacific Northwest Labs., Richland, Wash. (USA); USAEC Division of Biomedical and Environmental Research, Washington, D.C.
• NSA Number: NSA-33-023477
• OSTI ID: 4062044
• Report Number(s): CONF-740930--
• Country of Publication: United States
• Language: English

Related Subjects

*IMMUNE REACTIONS-- BIOLOGICAL RADIATION EFFECTS
*LEUKEMIA-- RADIOINDUCTION
*STRONTIUM 90-- LEUKEMOGENESIS
*X RADIATION-- LEUKEMOGENESIS
560151* --Biomedical Sciences
Applied Studies--Radiation Effects--Radiation Effects on Animals--Man
COMPARATIVE EVALUATIONS
FRACTIONATED IRRADIATION
INTERNAL IRRADIATION
INTRAPERITONEAL INJECTION
MICE
N48510* --Life Sciences--Radiation Effects on Animals--Man
WHOLE-BODY IRRADIATION