HISTOGENESIS OF Sr$sup 90$-INDUCED OSTEOSARCOMAS
Five hundred and thirty mice were injected intraperitoneally with Sr/sup 90/ and then killed in groups at intervals from 6 hours to 10 months later. The mice were examined roentgenologically before being autopsied and histological specimens were prepared from the femur, tibia, humerus, thoracic and lumbar vertebrae, ribs, and calotte. The first change, an increase in the number of osteoblasts in the metaphysis, was seen at 4 and 8 days after the injection of Sr/ sup 90/. After 8 days there was an increase in the number of osteoclasts. At the same time fiber formation commenced in the marrow adjacent to the endosteum. From 2 to 4 months after injection abundant argyrophilic and collagen fibers as well as a coarse-fibered, basophilic, acellular bone were formed. By 4 to 6 months, intramedullary tumors, osteosarcoma buds, appeared near the distal epiphyseal plate in the femur and the proximal plates in the tibia and humerus, i.e., adjacent to the regions where the radiation reaction was most severe. The majority of the osteoblastic tumors originated in the endosteum, probably from cells in the osteogenic connective tissue. Fibroblastic osteosarcomas arise from the endosteum and also from reticular cells in the medullary cavity. The osteosarcoma buds are often multiple along the endosteum of a bone. The intramedullary tumors are autonomous and transplantable from an early stage in their development. (38 references.) (auth)
- Research Organization:
- Research Inst. of National Defence, Sundbyberg, Sweden
- NSA Number:
- NSA-16-031478
- OSTI ID:
- 4778486
- Journal Information:
- Acta Veterinaria Scandinavica (Denmark), Journal Name: Acta Veterinaria Scandinavica (Denmark) Vol. Vol: 3; ISSN AVSCA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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