ON AN INCREASE OF THE RADIOPROTECTIVE ACTION OF S-$beta$- AMINOETHYLISOTHIURONIUM. HBr BY DIMETHYLSULFOXIDE (in German)
Journal Article
·
· Acta Biologica et Medica Germanica (East Germany)
OSTI ID:4772919
The survival rate and survival time were determined in mice irradiated with whole-body doses of 1000 and 1300 r, respectively, and treated with S- BETA - aminoethylisothiuronium bromide (AET), with and without dimethylsulfoxide. In irradiated untreated mice receiving 1000 r, all animals were dead by the 12th postirradiation day. In mice pretreated with 6 mg. AET, deg 25% survived beyond the 3Oth day, and when 95 mg. dimethylsulfoxide was given with the same amount of AET the 30-day survival rate exceeded 50%. In mice irradiated with 1300 r and given both compounds the mean survival time was 13 days compared with 9 days in rats given AET alone. Half these doses of both compounds were also effective but to a lesser extent. The promoting effect of dimethylsulfoxide on the radioprotective action of AE T probably doe s not involve chemical interaction between the 2 compounds. However, since dimethylsulfoxide is a good solvent medium, it may ensure a better distribution of AET throughout the body and thus enhance its protective action. (H.H.D.)
- Research Organization:
- Forschungsgemeinschaft der Deutschen Akademie der Wissenschaften, Berlin
- NSA Number:
- NSA-17-001337
- OSTI ID:
- 4772919
- Journal Information:
- Acta Biologica et Medica Germanica (East Germany), Journal Name: Acta Biologica et Medica Germanica (East Germany) Vol. Vol: 9; ISSN ABMGA
- Country of Publication:
- Country unknown/Code not available
- Language:
- German
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