TOXICOLOGICAL AND RADIOPROTECTION STUDIES ON S,/cap beta/- AMINOETHYLISOTHIURONIUM BROMIDE (AET)
AET was moderately toxic when administered in single doses to mice, rats, rabbits, guinea pigs, and cats. When given by intravenous injection, doses ranging from 50 to 450 mg/kg were lethal; by intraperitoneal injection, the lethal range was 350 to 650 mg./kg. Administered orally as a single dose, the lethal range was 250 to 1000 mg/kg. Rats fed dietary levels of 0.1%, 0.3%, and 0.5% for a period of 1 month showed no effects on growth. A 1.0% dietary level produced a moderate depression of growth. An increase in white cell counts was observed at all dietary levels of AET. No histological lesions were found that could be attributed to the ingestion of AET. The protective effects of S, BETA aminoethylisothiuronium - Br - HBr - (AET) against the lethal effects of 594 r of 1-Mev x radiation was tested in 21 dogs, with 14 additional dogs as controls. Data presented indicate failure of this compound to enhance survival or survival rate. (auth)
- Research Organization:
- Univ. of Rochester School of Medicine and Dentistry, N.Y.
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-16-001637
- OSTI ID:
- 4819996
- Journal Information:
- Radiation Research, Journal Name: Radiation Research Vol. Vol: 15
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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