COMPARATIVE EFFECTS OF INTRAPERITONEAL AND ORAL ADMINISTRATION OF AET ON SURVIVAL OF X-IRRADIATED RATS

Journal Article · Sat Aug 01 04:00:00 EDT 1959 · Radiation Research

DOI:https://doi.org/10.2307/3570664· OSTI ID:4235573

Preston, R L; Wells, A F; Ershoff, B H

The effects of intraperitoneal and oral administration of graded levels of AET were determined on the survival of rats exposed to 900 r of total-body x irradiation, a dose which was lethal for unprotected rats. Intraperitoneal adininistration of AET at a level of 300 mg/kg of body weight shortly before exposure to x irradiation resulted in a highly significant increase in length of survival. When administered by intraperitoneal injection at a level of 400 mg/kg of body weight, however, AET not only failed to increase but actually decreased survival as compared to that of untreated controls. In contrast to the results obtained with intraperitoneally administered AET, oral administration of AET by stomach tube (at levels of 400 or 800 mg/kg of body weight) shortly before x irradiation or mixed in the diet and fed at graded levels (1, 2.5, 5, or 10 gm/kg of diet) prior to and after x irradiation was without of significant effect in increasing the survival of x-irradiated rats. (auth)

• Research Organization: Western Biological Laboratories, Culver City, Calif.
• Sponsoring Organization: USDOE
• NSA Number: NSA-13-018846
• OSTI ID: 4235573
• Journal Information: Radiation Research, Journal Name: Radiation Research Vol. Vol: 11
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

AET
BIOLOGY AND MEDICINE
BODY
CONTROL
DIET
LETHAL DOSE
ORGANIC SULFUR COMPOUNDS
RADIATION PROTECTION
RATS
STOMACH
SURVIVAL TIME
X RADIATION