ON THE PATHOGENESIS OF POSTIRRADIATIVE HYPOPROTEINEMIA (in German)
To investigate the cause of postirradiation hypoproteinemia in cancer patients, the extravasation of intravenously injected I/sup 131/-labeled polyvinylpyrroiidone (PVP) was investigated in irradiated mice. PVP-I/sup 131/ was injected 2 to 10 days after whole-body irradiation with 500, 700, 800, or 900 r, and appearance of radioactivity in intestinal contents was followed. As earlier as the 2nd day after irradiation the activity of cecal contents was higher than in nonirradiated controls. Max. activity was reached on the 4th day, and then it declined to near normal by the 8th day with doses up to 800 r. After 900 r the activity reached a higher peak and remained higher longer than after the lower doses. Total serum protein and particularly albumin began to fall by the 2nd day. They returned to normal by the 8th to 10th day after 500 and 700 r, but after 800 and 900 r continued to fall during the 10-day observation period. Globulin fractions rose slightly after the lower doses. Enteric loss of serum proteins, therefore, appears to partially explain postirradiation hypoproteinemia. (H.H.D.)
- Research Organization:
- Tiefenauspital, Bern
- NSA Number:
- NSA-17-001354
- OSTI ID:
- 4772633
- Journal Information:
- Schweiz. Med. Wochschr., Journal Name: Schweiz. Med. Wochschr. Vol. Vol: 92
- Country of Publication:
- Country unknown/Code not available
- Language:
- German
Similar Records
THE BIOSYNTHESIS OF SERUM ALBUMIN IN RATS DURING RADIATION SICKNESS
Epilation induced by x-rays in guinea pigs