ANIMAL EXPERIMENTAL STUDIES ON THE PROBLEM OF POSTIRRADIATION EXUDATIVE ENTEROPATHY (in German)
Previous studies showed that whole-body irradiation of rats and mice with 250 to 1000 r caused a progressively increasing loss of proteins from blood into the intestinal lumen. This extravasation of plasma proteins was investigated in mice given single 700- or 800-r doses of wholebody irradiation by following the appearance of intravenously tracers in the cecal contents 2 to 10 days later. These tracers were I/sup 131/-labeled polyvinylpyrrolidone (PVP) of molecular weight 35,000 and 180,000, triolein-I/sup 131/, and free I/sup 131/. By the 2nd day after irradiation the cecal content of ail test substances were higher than in nonirradiated controls, and by the 4th day this difference was marked. On succeeding days cecal radioactivity declined with all test substances, but on the l0th day PVP-I/sup 131/ intestinal content rose again. Thus extravasation of macromoiecules shows a double maximal response 4 and 10 days after irradiation, whereas small molecules show only a monophasic peak. The PVP loss was 3 to 4 times greater than in nonirradiated mice. (H.H.D.)
- Research Organization:
- Tiefenauspital, Bern.
- NSA Number:
- NSA-17-001355
- OSTI ID:
- 4772632
- Journal Information:
- Schweiz. Med. Wochschr., Journal Name: Schweiz. Med. Wochschr. Vol. Vol: 92
- Country of Publication:
- Country unknown/Code not available
- Language:
- German
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