ALBUMIN LOSS AND FAECAL EXCRETION OF POLYVINYLPYRROLIDONE IN X-IRRADIATED MICE WITH IMPLANTED RAT BONE-MARROW
Protein-loss in x-irradiated mice implanted with rat bone-marrow was studied, using I/sup 131/-labelled human-serum albumin, and gastro-intestinal loss of macromolecules was studied, using the enzyme-resisting macromolecule I/ sup 131/labelled polyvinylpyrrolidone. Comparisons were made with normal control mice and with irradiated mice treated with isologous bone marrow. An increase in the fractional rate of loss of serum albumin occurred in the rat-marrowinjected mice in the second week after treatment and in some animals persisted at least 10 weeks; liver hypertrophy was also observed. Fecal excretion of labelled polyvinylpyrrolidone was generally greatest in the mice treated with rat marrow, suggesting that in these mice the wall of the gastrointestinal tract is abnormally permeable to macromolecules. (auth)
- Research Organization:
- Oak Ridge National Lab., Tenn.
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-16-014517
- OSTI ID:
- 4798559
- Journal Information:
- Intern. J. Radiation Biol., Journal Name: Intern. J. Radiation Biol. Vol. Vol: 4
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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