ALBUMIN LOSS AND FAECAL EXCRETION OF POLYVINYLPYRROLIDONE IN X-IRRADIATED MICE WITH IMPLANTED RAT BONE-MARROW

Journal Article · Thu Feb 01 04:00:00 EST 1962 · Intern. J. Radiation Biol.

DOI:https://doi.org/10.1080/09553006214550251· OSTI ID:4798559

Friedberg, W; Jenkins, V K; Muederrisoglu, O V

Protein-loss in x-irradiated mice implanted with rat bone-marrow was studied, using I/sup 131/-labelled human-serum albumin, and gastro-intestinal loss of macromolecules was studied, using the enzyme-resisting macromolecule I/ sup 131/labelled polyvinylpyrrolidone. Comparisons were made with normal control mice and with irradiated mice treated with isologous bone marrow. An increase in the fractional rate of loss of serum albumin occurred in the rat-marrowinjected mice in the second week after treatment and in some animals persisted at least 10 weeks; liver hypertrophy was also observed. Fecal excretion of labelled polyvinylpyrrolidone was generally greatest in the mice treated with rat marrow, suggesting that in these mice the wall of the gastrointestinal tract is abnormally permeable to macromolecules. (auth)

• Research Organization: Oak Ridge National Lab., Tenn.
• Sponsoring Organization: USDOE
• NSA Number: NSA-16-014517
• OSTI ID: 4798559
• Journal Information: Intern. J. Radiation Biol., Journal Name: Intern. J. Radiation Biol. Vol. Vol: 4
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ALBUMINS
BIOLOGY AND MEDICINE
BLOOD SERUM
BONE MARROW
CHEMICALS
DIFFUSION
ENZYMES
FECES
GRAFTS
INTESTINE
IODINE 131
LIVER
MICE
ORGANIC NITROGEN COMPOUNDS
POLYVINYLS
PROTEINS
PVP
PYRROLIDONES
QUANTITY RATIO
STOMACH
TRACER TECHNIQUES
TRANSPLANTS
X RADIATION