THE BIOSYNTHESIS OF SERUM ALBUMIN IN RATS DURING RADIATION SICKNESS (in Russian)
An immunological chemical method developed by Khesin and Campbell was used to evaluate the synthesis of serum albumin in the liver of irradiated rats which had been given an x ray dose of 900 r. The rats were killed on the 4th to 11th day after irradiation, and 100 mg slices of liver were incubated for 3 hours at 38 deg C. The albumin concentration in the blood serum was unchanged 24 hours after the irradiation, but began to fall off on the third day after irradiation. In most cases, the synthesis of serum albumin is almost completely inhibited on the 8th day after irradiation, and the initial amount of albumin in the liver slices was considerably decreased. The suppression of albumin synthesis is not a result of the direct action of ionizing radiation, but is accompanied by a general disruption in protein synthesis which is manifested on the 6th day after irradiation. The synthesis and total amount of albumin decrease in parallel. (TTT).
- Research Organization:
- Inst. of Biological and Medicinal Chemistry, Moscow
- NSA Number:
- NSA-17-005928
- OSTI ID:
- 4750131
- Journal Information:
- Radiobiologiya (U.S.S.R.) For English translation see Radiobiology (Engl. Transl.), Journal Name: Radiobiologiya (U.S.S.R.) For English translation see Radiobiology (Engl. Transl.) Vol. Vol: 2; ISSN RADOA
- Country of Publication:
- Country unknown/Code not available
- Language:
- Russian
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