MEDICAL DIVISION RESEARCH REPORT FOR 1961

Technical Report · Tue Oct 30 23:00:00 EST 1962

DOI:https://doi.org/10.2172/4771235· OSTI ID:4771235

Progress is reported in a number of diverse studies on radiation effects in man and experimental animals. Biochemical, immunologic, and hematologic studies were carried out on patients given whole-body irradiation in low, medium, and high dose ranges. Emphasis was placed on remission in acute leukemia after whole-body irradiation. Results are also summarized from studies on the effects of local port irradiation, with gamma radiation from a Co/sup 60/ teletherapy unit, on the peripheral blood and bone marrow in patients; bone marrow lipid levels in animals exposed to whole-body irradiation; liver damage in irradiated ani-mals given bone marrow infusions; nitrogen balance in irradiated chimeras; the effects of injected radionuclides on lipid metabolism; and the effects of stable Ce on liver lipids. A comparative study was made of results using Au/sup 198/ I/sup 131/-labeled rose bengal, or I/sup 131/-labeled serum albumin for liver scanning in patients with liver disease. An in vivo tissue culture system for the propagation of human cells was investigated for use in studies of antibody formation. Investigations are reported underway on the feasibility of using a small South American primate, Tamarinus nigricollis, as a laboratory animal for radiation studies. Special equipment designed for clinmcal work with radioisotopes is described. A schematic sketch is presented of an apparatus for in vivo C/sup 14/O/sub 2/ collection and subsequent scintillation counting. A list is included of publications during the period covered by this report. (C.H.)

• Research Organization: Oak Ridge Inst. of Nuclear Studies, Inc., Tenn.
• NSA Number: NSA-16-030212
• OSTI ID: 4771235
• Report Number(s): ORINS-41
• Country of Publication: United States
• Language: English

Related Subjects

ANIMALS
BIOCHEMISTRY
BIOLOGY AND MEDICINE
BLOOD
BODY
BONE MARROW
CERIUM
COBALT 60
DISEASES
GAMMA RADIATION
IMMUNITY
IRRADIATION
LEUKEMIA
LIPIDS
LIVER
MAN
MEDICINE
METABOLISM
MONKEYS
QUANTITY RATIO
RADIATION DOSES
RADIATION EFFECTS
RADIATION INJURIES
RADIOBIOLOGY
RADIOISOTOPES
RADIOTHERAPY
RECOVERY
TRANSPLANTS