OAK RIDGE INSTITUTE OF NUCLEAR STUDIES MEDICAL DIVISION REPORT FOR 1959
Studies associated with whole-body irradiation followed by attempts at bone-marrow grafts in acute leukemia patients were continued. Data were compared with results reported by other workers. Results are reported from studies on the effects of both whole-body and local-port irradiation on various hematological diseases, other clinical syndromes, and normal hematopoietic tissues. It was demonstrated that large doses of whole-body irradiation alone can produce remissions in leukemia. Results are reported on a group of patients who received autologous bone marrow grafts after a single large dose of nitrogen mustard. Clinical results are reported on a group of eleven patients with acute or subacute leukemia given a single large dose of whole-body irradiation, varying from 200 r to more than 900 r, followed by intravenously administered bone marrow from homologous doners cross matched for the usual major blood types. A summary is included of current impressions of the treatment of leukemia by irradiation and marrow grafting. Pathological changes following whole-body irradiation are discussed. Results are reported from clinical studies on 8 men exposed to wholebody radiation 9 months previously during the Y-12 accident. A comparison is made in data on the Y-12 patients and data on the Yugoslavian accident victims. Procedures for the recovery of amino acids from solutions are discussed and data are tabulated on daily variation in levels of urinary amino acids, and the effects of whole-body irradiation or nitrogen mustard on urinary excretion of amino acids. Research with internal isotopes was continued and progress is reported in the development of scanning equipment and in interpretation of results. Teletherapy treatments were given to 64 patients suffering from lymphomas of several types. Summaries are included of experimental work on the properties and localization by linear scanning of calcium-47 in rats: the distribution of radioactive colloidal yttrium in rats; selective irradiation by the intralymphatic injection of radioactive preparations; metabolism of rare earths; and liver-liquid response to radiocerium. The design and calibration are described of a whole-body irradiator employing 8 cesium-137 teletherapy machines. New designs and design modifications are described for equipment for scanning and radiation therapy. A training program is outlined. A list of publications during the period is included. (C.H.)
- Research Organization:
- Oak Ridge Inst. of nuclear Studies, Inc., Tenn. Page(s): 87
- NSA Number:
- NSA-14-018737
- OSTI ID:
- 4152028
- Report Number(s):
- ORINS-34
- Country of Publication:
- United States
- Language:
- English
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