THE EFFECT OF THYROXINE ON ERYTHROPOIESIS N IRRADIATED ANIMALS (in Russian)
Journal Article
·
· Radiobiologiya (U.S.S.R.) For English translation see Radiobiology (Engl. Transl.)
OSTI ID:4766864
An increase in activity of the thyroid gland is accompanied by activation of erythropoiesis which can be detected by an increase in the take-up of Fe/sup 59/ by hemoglobulin in the erythrocytes. Rats were given a dose of 750 and 850 r of Co/sup 60/ gamma -rays, and 2 to 4 months after the irradiation, the rate of incorporation of Fe/sup 59/ was found to be 150 to 190% of the level in the controls. This behavior indicates an increase in erythropoiesis due to the increased destruction of erythrocytes in the peripheral blood. On adding a supplement of 10 and 25 mgs of thyroxine daily to the diet of the rats during the 2nd and 4th months after the irradiation, an increase in the number of erythrocytes in the peripheral blood was observed, and the rate of take-up of Fe/ sup 59/ was almost normal. The addition of thyroxine was more effective in females than in males. Treatment with thyroxine during the 4th month was more effective than treatment during the 2nd month after irradiation. It is beiieved that the addition of thyroxine removes a hormonal deficiency in the onganism, and creates conditions which prevent the accelerated destruction of erythrocytes. (TTT)
- Research Organization:
- Originating Research Org. not identified
- NSA Number:
- NSA-17-005883
- OSTI ID:
- 4766864
- Journal Information:
- Radiobiologiya (U.S.S.R.) For English translation see Radiobiology (Engl. Transl.), Journal Name: Radiobiologiya (U.S.S.R.) For English translation see Radiobiology (Engl. Transl.) Vol. Vol: 2; ISSN RADOA
- Country of Publication:
- Country unknown/Code not available
- Language:
- Russian
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