STIMULATION OF ERYTHROPOIESIS IN MICE BY PERORAL ADMINISTRATION OF THE URINE OF ANEAEMIC ANIMALS
When irradiated mice and non-irradiated controls were kept together in the same cage, erythropoiesis in the control mice was affected. During the period of anemia in the irradiated mice, an increase occurred in the degree of erythropoiesis in the controls. The method of incorporation of Fe/sup 59/ into the erythrocytes and of the reticulocyte count was used. The addition of the urine of anemic animals to the food of normal mice resulted in an increase in the total number of reticulocytes after four days. The increase in the total number of reticulocytes caused by administering ''anemic urine'' was not accompanied by parallel changes in the white blood picture. It is therefore assumed that the effective substance in ''anemic'' urine is a substance resembling ''hemopoietin.'' The question of the significance of the peroral effectiveness of anemic urine in relation to the structure of erythropoietin (hemopoietin) is briefly discussed. (auth)
- Research Organization:
- Czechoslovak Academy of Sciences, Brno
- NSA Number:
- NSA-13-016688
- OSTI ID:
- 4241712
- Journal Information:
- Folia Biologica (Prague) (Czechoslovakia), Journal Name: Folia Biologica (Prague) (Czechoslovakia) Vol. Vol: 5; ISSN FOBLA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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