STUDIES ON ERYTHROPOIESIS

Technical Report · Thu Oct 30 23:00:00 EST 1958

OSTI ID:4329404

Jacobson, L O; Goldwasser, E; Gurney, C W; Fried, W; Plzak, L F

c the rate of incorporation of Fe/su p59/ into the red cells of recipient normal rats. Hypophysectomy of rats reduces erythropoiesis to a minimum within 1 to 3 weeks. The mmature rats than in young adult rats. Hypophysectomized rats are sensitive to anemic plasma, especially during the at its minium. The response of hypophysectomized animals in terms of reticulocyte or Fe/sup 59/ red blood cells mal rats. Hypophysectomized rats retain the capacity to produce erythropoietin in response to bleeding. Transfusion-induced polycythemia in rats and mice, acute starvation in rats, and hyperoxia in rats, all rapidly reduce erythropoiesis. Experimental animals in these conditions are sensitive in their repsonse to the injection of erythropoietin. The rate of erythropoiesis, as determined by the quantity of circulating erythropoietin depends on the relationship of osygen supply to oxygen demand in the tissue rather than to either factor acting alone. Injection of cobaltous chloride increases rabbits within 10 to 12 hous. After bilaterial nephrectomy, Co/sup 2+/ administration acute hemorrhage, or hypoxic hypoxcia fails to a elevate plasma erythropoietin, whereas bilateral ureter ligation reduces but does not eliminate the erythropoietin plasma elevation. After removal of adrenals, gonads, stomach, intestines, spleen, pancreas, thymus, or 90 per cent of the liver, an increase in plasma erythropoietin does occur in response to cobalt or bleeeding. These observations suggest that the kidney may be the site of erythropoietin production (auth)

• Research Organization: Argonne Cancer Research Hospital, Chicago; Chicago. Univ.
• NSA Number: NSA-12-014569
• OSTI ID: 4329404
• Report Number(s): A/CONF.15/P/847
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ADRENAL GLANDS-- BLOOD PLASMA-- COBALT CHLORIDES-- ERYTHROPOIETIN-- GLANDS-- GONADS-- HEMORRHAGE-- HORMONES-- INTESTINE-- KIDNEYS-- LIVER-- PANCREAS-- PHYSIOLOGY-- PRODUCTION-- QUANTITY RATIO-- SPLEEN-- STOMACH-- SURGERY-- THYMUS-- VARIATIONS
AGE-- ANEMIA-- ANIMALS-- BLOOD FORMATION-- BLOOD PLASMA-- CONFERENCE-- CYTOLOGY-- DISEASES-- ERYTHROCYTES-- ERYTHROPOIETIN-- GLANDS-- HEMORRHAGE-- HORMONES-- IRON 59-- MAN-- METABOLISM-- PHYSIOLOGY-- PITUITARY GLAND-- PRODUCTION-- QUANTITY RATIO-- RATS-- RETICULOCYTES-- SENSITIVITY-- SURGERY-- VARIATIONS
BIOLOGY AND MEDICINE
BLOOD-- BLOOD CIRCULATION-- BLOOD FORMATION-- BLOOD PLASMA-- CARBON DIOXIDE-- COBALT CHLORIDES-- DI