SEMIANNUAL REPORT TO THE ATOMIC ENERGY COMMISSION. STUDIES ON ERYTHROPOIESIS
Progress is reported in studies directed toward an understanding of the mechanism of control of red blood cell formation. A relatively rapid and sensitive method of assay for erythropoietin was developed, using the rate of incorporation of iron-59 into the red cells of normal, hypophysectomized, or starved rats as a measure of the rate of erythropoiesis. Factors that control erythropoiesis through control of production of erythropoietin were studied. The effect of erythropoietin in initiating marrow activity was demonstrated in mice having a completely suppressed marrow as far as red cell formation is concerned. Data are reported from studies on the effect of cobalt in polycythemia, the site of erythropoietin production, the clinical significance of erythropoietin, the production of erythropoietin by fetuses in utero, the effect of erythropoietin on iron absorption, and the properties of erythropoietin isolated from plasma. A list of publications during the period is included. (C.H.)
- Research Organization:
- Argonne Cancer Research Hospital, Chicago
- NSA Number:
- NSA-13-008486
- OSTI ID:
- 4281814
- Report Number(s):
- ACRH-8
- Country of Publication:
- United States
- Language:
- English
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