STUDY ON X-IRRADIATION OF THE HYPOPHYSIS. III. EFFECT ON WHOLE-BODY IMMUNITY

Journal Article · Fri Jan 01 04:00:00 EST 1960 · Nagoya Shiritsu Daigaku Igakkai Zasshi (Japan)

OSTI ID:4758809

Miwa, H

Irradiation of the hypophysis with 100 r increased wholebody immunity and induced lymphopenia in the peripheral blood. However, after 1000 r the whole- body immunity ap, peared to be reduced and was associated with lymphocytosis in the peripheral blood. An increased whole-body immunity and lymphoperia also resulted from the administration of ACTH. A large dose of androsterone induced a reduction in the general immunity and a lymphocytosis. Therefore, there may be some relationship between the hypophyseo-adrenocortical function, the general immunity, and the lymphocyte count in peripheral blood. A reduction in the general immunity after androsterone was prevented by a 100 r irradiation of the hypophysis. As an increase in general immunity inhibited the proliferation of cancer cells. long-term administration of androsterone in breast cancer might be endocrinologically rational. (Abstr. Japan Med., 2: No. 10, Oct. 1962)

• Research Organization: Nagoya City Univ. Medical School, Japan
• NSA Number: NSA-17-004407
• OSTI ID: 4758809
• Journal Information: Nagoya Shiritsu Daigaku Igakkai Zasshi (Japan), Journal Name: Nagoya Shiritsu Daigaku Igakkai Zasshi (Japan) Vol. Vol: 11; ISSN NASDA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ACTH
BIOLOGY AND MEDICINE
CANCER
CLEANING
CORROSION
GASES
GLANDS
HORMONES
HUMIDITY
HYPOPHYSIS
IMMUNITY
LYMPHOCYTES
MAMMARY GLANDS
MAN
MEDICINE
QUANTITY RATIO
RADIATION DOSES
SEX
THERAPY
VESSELS
X RADIATION