Nature of the Photoreactivable Ultra-Violet Lesion in Deoxyribonucleic Acid
Reaction mechanisms involved in the reactivation of biological activity of ultraviolet-inactivated transforming desoxyribonucleic acid were investigated. Emphasis was placed on the role of thymine dimers in biological reactivation in Escherichia coli desoxyribonucleic acid split by treatment with a yeast extract in the presence of light. Results from a series of studies indicate that the yeast photoreactivating preparation had little or no biological effect except that resulting from breakage of thymine dimers. It is concluded that the proportion of photoreactivable damage varies with different wave-lengths of inactivating radiation. (C.H.)
- Research Organization:
- Oak Ridge National Lab., Tenn.
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-17-014058
- OSTI ID:
- 4758030
- Journal Information:
- Nature (London), Journal Name: Nature (London) Journal Issue: 4867 Vol. 197; ISSN 0028-0836
- Publisher:
- Nature Publishing Group
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
Similar Records
ULTRAVIOLET LIGHT INDUCED LINKING OF DEOXYRIBONUCLEIC ACID STRANDS AND ITS REVERSAL BY PHOTOREACTIVATING ENZYME
Effect of potassium nitrate on photoreactivation of Escherichia coli cells
DEOXYRIBONUCLEIC ACID INSTABILITY IN THE PRESENCE OF CHLORAMPHENICOL IN ULTRA-VIOLET-LIGHT-EXPOSED BACTERIA
Journal Article
·
Thu Jun 01 00:00:00 EDT 1961
· Proc. Natl. Acad. Sci. U.S.
·
OSTI ID:4068056
Effect of potassium nitrate on photoreactivation of Escherichia coli cells
Journal Article
·
Fri Nov 30 23:00:00 EST 1973
· Z. Naturforsch., v. 28, no. 11-12, pp. 757-760
·
OSTI ID:4311482
DEOXYRIBONUCLEIC ACID INSTABILITY IN THE PRESENCE OF CHLORAMPHENICOL IN ULTRA-VIOLET-LIGHT-EXPOSED BACTERIA
Journal Article
·
Thu Mar 09 23:00:00 EST 1961
· Biochem. Biophys. Research Communs
·
OSTI ID:4070692